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However, as insulin sensitivity eventually declines and insulin demand rises, -cells can no longer sustain insulin production, and the patient enters the dysfunctional (decompensated) stage, where hypoinsulinemia, hyperglycemia, and dyslipidemia appear (Hu et al., 2022)

Ann Intern Med 104:427429 Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L (2001) Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial

J Clin Invest 98:116124 Wang SN, Hirschberg R (1999) Tubular epithelial cell activation and interstitial fibrosis